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Cell Permeable Peptides

21st Century Biochemicals Scientists Are Co-Authors on Two Cell-Permeable Peptide Papers! A recent paper in the J. Biological Chemistry from the laboratory of John Johnson at the Medical College of GA demonstrated the ability of cell-permeable peptides derived from PKC delta to modify the activity of the F1F0-ATPase in mitochondria. This study clearly demonstrates the ability to deliver peptide cargo to the mitochondria and to either activate or inhibit enzyme activity. The close collaboration between Dr. Johnson's laboratory and Dr. Jordan Fishman is indicative of the collaborative relationship between the scientists at 21st  Century Biochemicals and our customers around the world. See: Modulation of the Delta Protein Kinase C Interaction With The "d" Subunit of F1Fo ATP Synthase in Neonatal Cardiac Myocytes: Development of Cell-Permeable, Mitochondrial-Targeted Inhibitor and Facilitator Peptides. Tiffany T. Nguyen, Mourad Ogbi, Qilin Yu, Jordan B. Fishman, Warren Thomas, David Fulton, and John A. Johnson. July, 2010. J. Biol. Chem., 285: 22164 - 22173 In a second paper, the laboratory of Dr. Peter Polgar, along with Drs. Berg and Fishman of 21st Century Biochemicals demonstrate that peptides can be used to modulate angiotensin receptor signaling through the calcium/PI turnover while having no effect of ERK activation. The use of cell-permeable peptides to delineate regulation of various arms of receptor signaling offers an advantage over the use of siRNA and similar knock-down technologies, where multiple signaling pathways would be affected. See: Limiting angiotensin II signaling with a cell penetrating peptide mimicking the second intracellular loop of the angiotensin II type I receptor. Jun Yu, Linda Taylor, Dale Mierke, Eric Berg, Jordan Fishman, and Peter Polgar. 2010. Chem. Biol. & Drug Design, Chem Biol Drug Des, July 1, 2010; 76(1): 70-6.


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